Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC010
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-07-05 11:41
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar 250 4x1 caps Madopar HBS 2 uvece

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 5 individuals with a value less than 0.52 were subsequently diagnosed with PD. That is, 11.9% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.52 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 40, 'TN': 29, 'TP': 2, 'FP': 1}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 8, 'TN': 9, 'TP': 34, 'FP': 21}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 39, 'TN': 29, 'TP': 3, 'FP': 1}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 13, 'TN': 9, 'TP': 29, 'FP': 21}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 20.768
timePerCircleCoV 0.219091
timePerCircleSlope -0.0673063
meanError 1.5086
tremorFreq 6.83594
tremorRelPower 38.6456
tremorGyroAmpMean 0.0227182
tremorGyroAmpSlope -0.00031099
tremorGyroAmpCoV 0.450728
tremorCoordAmpMean 0.0233307
tremorCoordAmpSlope -0.000552376
tremorCoordAmpCoV 0.341371
tremorAccAmpMean 0.0183234
tremorAccAmpSlope -0.000797359
tremorAccAmpCoV 0.452661
tremorPcRelVar 0.613841
tremorPcX 0.847845
tremorPcY 0.530245

Circle Segment 1

Duration 28.44 s, Accuracy Estimate 2.947 (lower is better)

Circle Segment 2

Duration 28.16 s, Accuracy Estimate 1.156 (lower is better)

Circle Segment 3

Duration 21.2 s, Accuracy Estimate 1.122 (lower is better)

Circle Segment 4

Duration 22.32 s, Accuracy Estimate 1.361 (lower is better)

Circle Segment 5

Duration 21.52 s, Accuracy Estimate 1.149 (lower is better)

Circle Segment 6

Duration 18.08 s, Accuracy Estimate 1.35 (lower is better)

Circle Segment 7

Duration 18.24 s, Accuracy Estimate 1.223 (lower is better)

Circle Segment 8

Duration 17.08 s, Accuracy Estimate 1.199 (lower is better)

Circle Segment 9

Duration 17.52 s, Accuracy Estimate 1.268 (lower is better)

Circle Segment 10

Duration 15.12 s, Accuracy Estimate 2.31 (lower is better)

Spiral

numSpirals 6
timePerSpiralMean 48.08
timePerSpiralCoV 0.0849792
timePerSpiralSlope -0.00922272
meanError 1.8269
tremorFreq 6.34766
tremorRelPower 35.4604
tremorGyroAmpMean 0.0170015
tremorGyroAmpSlope -0.000236813
tremorGyroAmpCoV 0.403587
tremorCoordAmpMean 0.0273899
tremorCoordAmpSlope 0.00135437
tremorCoordAmpCoV 0.472795
tremorAccAmpMean 0.0451656
tremorAccAmpSlope -1.18404e-05
tremorAccAmpCoV 0.119195
tremorPcRelVar 0.660614
tremorPcX 0.908192
tremorPcY 0.418554

Spiral Segment 1

Duration 53.32 s, Accuracy Estimate 1.731 (lower is better)

Spiral Segment 2

Duration 43.8 s, Accuracy Estimate 1.742 (lower is better)

Spiral Segment 3

Duration 50.92 s, Accuracy Estimate 1.869 (lower is better)

Spiral Segment 4

Duration 44.84 s, Accuracy Estimate 1.926 (lower is better)

Spiral Segment 5

Duration 44.72 s, Accuracy Estimate 1.981 (lower is better)

Spiral Segment 6

Duration 50.88 s, Accuracy Estimate 1.713 (lower is better)

Elel

eDurationMean 1.115
eDurationStd 0.371042
eDurationStdnorm 0.332773
eDurationMedian 1.0225
eDurationQuartdelta 0.62
eDurationQuartdeltanorm 0.606357
eDurationKurt 1.95004
eDurationTrenddiff -0.45
eDurationTrendratio 0.690722
eWidthMean 4.5981
eWidthStd 2.13045
eWidthStdnorm 0.463333
eWidthMedian 4.797
eWidthQuartdelta 4.212
eWidthQuartdeltanorm 0.878049
eWidthKurt 1.53816
eWidthTrenddiff -2.808
eWidthTrendratio 0.510204
eHeightMean 9.2196
eHeightStd 6.68934
eHeightStdnorm 0.725556
eHeightMedian 7.8975
eHeightQuartdelta 12.402
eHeightQuartdeltanorm 1.57037
eHeightKurt 1.75972
eHeightTrenddiff -4.797
eHeightTrendratio 0.438356
eAspectMean 0.633904
eAspectStd 0.251894
eAspectStdnorm 0.397369
eAspectMedian 0.637868
eAspectQuartdelta 0.370033
eAspectQuartdeltanorm 0.580109
eAspectKurt 2.04325
eAspectTrenddiff 0.0992647
eAspectTrendratio 1.16875
eSlantMean 0.168982
eSlantStd 0.155277
eSlantStdnorm 0.918894
eSlantMedian 0.212592
eSlantQuartdelta 0.25438
eSlantQuartdeltanorm 1.19656
eSlantKurt 1.72533
eSlantTrenddiff -0.139127
eRtopMean 0.669679
eRtopStd 0.168361
eRtopStdnorm 0.251405
eRtopMedian 0.707812
eRtopQuartdelta 0.25551
eRtopQuartdeltanorm 0.360986
eRtopKurt 1.79578
eRtopTrenddiff -0.132168
eRbotMean 0.362916
eRbotStd 0.169349
eRbotStdnorm 0.466633
eRbotMedian 0.401691
eRbotQuartdelta 0.22
eRbotQuartdeltanorm 0.547684
eRbotKurt 2.05031
eRbotTrenddiff 0.105708
eRrightMean 0.746946
eRrightStd 0.162962
eRrightStdnorm 0.218171
eRrightMedian 0.784533
eRrightQuartdelta 0.171657
eRrightQuartdeltanorm 0.218801
eRrightKurt 2.8451
eRrightTrenddiff 0.0383065
eRleftMean 0.252064
eRleftStd 0.158886
eRleftStdnorm 0.630338
eRleftMedian 0.234698
eRleftQuartdelta 0.166188
eRleftQuartdeltanorm 0.708093
eRleftKurt 3.10217
eRleftTrenddiff -0.0352564
lDurationMean 1.21147
lDurationStd 0.499493
lDurationStdnorm 0.412303
lDurationMedian 0.98
lDurationQuartdelta 0.925
lDurationQuartdeltanorm 0.943878
lDurationKurt 1.56682
lDurationTrenddiff -0.7575
lDurationTrendratio 0.551111
lWidthMean 6.91676
lWidthStd 1.38305
lWidthStdnorm 0.199957
lWidthMedian 6.552
lWidthQuartdelta 2.106
lWidthQuartdeltanorm 0.321429
lWidthKurt 2.19335
lWidthTrenddiff 0.5265
lWidthTrendratio 1.08108
lHeightMean 15.6436
lHeightStd 5.64665
lHeightStdnorm 0.360956
lHeightMedian 17.784
lHeightQuartdelta 7.98525
lHeightQuartdeltanorm 0.449013
lHeightKurt 1.96004
lHeightTrenddiff -1.17
lHeightTrendratio 0.935691
lAspectMean 0.516097
lAspectStd 0.229639
lAspectStdnorm 0.444953
lAspectMedian 0.448052
lAspectQuartdelta 0.372691
lAspectQuartdeltanorm 0.831802
lAspectKurt 2.02881
lAspectTrenddiff 0.0405749
lAspectTrendratio 1.09556
lSlantMean 0.191653
lSlantStd 0.213696
lSlantStdnorm 1.11501
lSlantMedian 0.184971
lSlantQuartdelta 0.256391
lSlantQuartdeltanorm 1.38611
lSlantKurt 3.51754
lSlantTrenddiff 0.122424
lRtopMean 0.784628
lRtopStd 0.148394
lRtopStdnorm 0.189127
lRtopMedian 0.822581
lRtopQuartdelta 0.19931
lRtopQuartdeltanorm 0.242299
lRtopKurt 3.47225
lRtopTrenddiff 0.108641
lRbotMean 0.384494
lRbotStd 0.283383
lRbotStdnorm 0.737029
lRbotMedian 0.291667
lRbotQuartdelta 0.34378
lRbotQuartdeltanorm 1.17867
lRbotKurt 3.93999
lRbotTrenddiff -0.250507
lRrightMean 0.857548
lRrightStd 0.11532
lRrightStdnorm 0.134477
lRrightMedian 0.900709
lRrightQuartdelta 0.112531
lRrightQuartdeltanorm 0.124936
lRrightKurt 3.65426
lRrightTrenddiff 0.0240797
lRleftMean 0.226135
lRleftStd 0.182594
lRleftStdnorm 0.807456
lRleftMedian 0.16
lRleftQuartdelta 0.276617
lRleftQuartdeltanorm 1.72885
lRleftKurt 2.8234
lRleftTrenddiff -0.263562

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

Elel Segment 14

Elel Segment 15

Elel Segment 16

Elel Segment 17

Elel Segment 18

Elel Segment 19

Elel Segment 20

Elel Segment 21

FITTS Short Modified

meanTouchScore 0.959644
sumTouchScores 20.1525
meanMovementTime 0.828
numTouches 21
undershootPercentage 0
overshootPercentage 0

FITTS Long Modified

meanTouchScore 0.923061
sumTouchScores 15.692
meanMovementTime 1.25
numTouches 17
undershootPercentage 0
overshootPercentage 17.6471

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 36.2
timePerZigzagCoV 0.0969735
timePerZigzagSlope -0.0268508
meanError 1.86144
tremorFreq 6.34766
tremorRelPower 29.2574
tremorGyroAmpMean 0.0183203
tremorGyroAmpSlope -6.7212e-05
tremorGyroAmpCoV 0.354992
tremorCoordAmpMean 0.031795
tremorCoordAmpSlope 0.00121343
tremorCoordAmpCoV 0.336951
tremorAccAmpMean 0.0469582
tremorAccAmpSlope 0.000312774
tremorAccAmpCoV 0.0995275
tremorPcRelVar 0.630127
tremorPcX 0.206144
tremorPcY -0.978522

ZigZag Segment 1

Duration 36.0 s, Accuracy Estimate 1.798 (lower is better)

ZigZag Segment 2

Duration 36.4 s, Accuracy Estimate 1.84 (lower is better)

ZigZag Segment 3

Duration 41.12 s, Accuracy Estimate 1.685 (lower is better)

ZigZag Segment 4

Duration 36.28 s, Accuracy Estimate 1.637 (lower is better)

ZigZag Segment 5

Duration 31.2 s, Accuracy Estimate 2.347 (lower is better)

ZigZag Offset

numZigzags 7
timePerZigzagMean 23.0171
timePerZigzagCoV 0.0832884
timePerZigzagSlope -0.0199851
zigzagHeightMean 68.2445
zigzagHeightCoV 0.110914
zigzagHeightSlope 0.0364222
meanError 0.0580684
tremorFreq 7.91016
tremorRelPower 26.7858
tremorGyroAmpMean 0.0133565
tremorGyroAmpSlope -0.00180681
tremorGyroAmpCoV 0.470195
tremorCoordAmpMean 0.0391906
tremorCoordAmpSlope -0.00198986
tremorCoordAmpCoV 0.682011
tremorAccAmpMean 0.0175812
tremorAccAmpSlope -0.000194254
tremorAccAmpCoV 0.358701
tremorPcRelVar 0.827704
tremorPcX 0.0501009
tremorPcY 0.998744

ZigZag Offset Segment 1

Duration 22.24 s, Accuracy Estimate 0.087 (lower is better)

ZigZag Offset Segment 2

Duration 26.12 s, Accuracy Estimate 0.122 (lower is better)

ZigZag Offset Segment 3

Duration 23.72 s, Accuracy Estimate 0.041 (lower is better)

ZigZag Offset Segment 4

Duration 22.72 s, Accuracy Estimate 0.034 (lower is better)

ZigZag Offset Segment 5

Duration 22.64 s, Accuracy Estimate 0.028 (lower is better)

ZigZag Offset Segment 6

Duration 23.88 s, Accuracy Estimate 0.029 (lower is better)

ZigZag Offset Segment 7

Duration 19.8 s, Accuracy Estimate 0.066 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.65}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.52}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.4364404917095519}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8547837551008155}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.47878504810881045}